Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in
the establishment of somatic expression programs during embryonic stem cell (ESC) …

In the past several decades, the establishment of in vitro models of pluripotency has ushered
in a golden era for developmental and stem cell biology. Research in this arena has led to …

Mesenchymal stromal/stem cells (MSCs) form a heterogeneous population of multipotent
progenitors that contribute to tissue regeneration and homeostasis. MSCs assess …

Embryonic stem cells (ESCs) are self-renewing and pluripotent. In recent years, factors that
control pluripotency, mostly nuclear, have been identified. To identify non-nuclear regulators …

Large-scale sequencing techniques to chart genomes are entirely consolidated. Stable
computational methods to perform primary tasks such as quality control, read mapping, peak …

Applying high-throughput DNA sequencing technologies to the ancient DNA molecules
preserved in subfossil material can provide genetic information from past individuals …

Protein function annotation and drug discovery often involve finding small molecule binders.
In the early stages of drug discovery, virtual ligand screening (VLS) is frequently applied to …

Osteoarthritis is the most prevalent joint disease worldwide, and it is a leading source of pain
and disability. To date, this disease lacks curative treatment, as underlying molecular …

Computer-aided drug designing (CADD) relates to drug discovery, also characterized as a
cost-effective and active tool that manages or creates theoretical models that would be used …

Accumulating evidence supports the role of the DNA damage response (DDR) in the
negative regulation of tumorigenesis. Here, we found that DDR signaling poises a series of …