Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
DR Cook, KL Rossman, CJ Der - Oncogene, 2014 - nature.com
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …
has been implicated in cancer and other human diseases. However, in contrast to the direct …
Creating order from chaos: cellular regulation by kinase anchoring
Second messenger responses rely on where and when the enzymes that propagate these
signals become active. Spatial and temporal organization of certain signaling enzymes is …
signals become active. Spatial and temporal organization of certain signaling enzymes is …
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a …
high mortality, uncertain cause, and few treatment options. Studies have identified a …
[HTML][HTML] Rho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells
M Ohgushi, M Minaguchi, Y Sasai - Cell stem cell, 2015 - cell.com
Human embryonic stem cells (hESCs) can survive and proliferate for an extended period of
time in culture, but unlike that of tumor-derived cells, this form of cellular immortality does not …
time in culture, but unlike that of tumor-derived cells, this form of cellular immortality does not …
Mechanisms of protein kinase A anchoring
P Skroblin, S Grossmann, G Schäfer… - International review of …, 2010 - Elsevier
The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …
[HTML][HTML] Networking with AKAPs: context-dependent regulation of anchored enzymes
Abstract A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …
AKAP signaling complexes: pointing towards the next generation of therapeutic targets?
JL Esseltine, JD Scott - Trends in pharmacological sciences, 2013 - cell.com
A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling
enzymes with their substrates. Great strides have been made in elucidating the role of these …
enzymes with their substrates. Great strides have been made in elucidating the role of these …
Small G proteins in the cardiovascular system: physiological and pathological aspects
G Loirand, V Sauzeau, P Pacaud - Physiological reviews, 2013 - journals.physiology.org
Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …
comprising more than 100 members. This superfamily is structurally classified into five …
AKAPs: the architectural underpinnings of local cAMP signaling
The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the
cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins …
cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins …
A‐kinase anchoring proteins as potential drug targets
J Tröger, MC Moutty, P Skroblin… - British journal of …, 2012 - Wiley Online Library
A‐kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control
of cellular signalling. They directly interact with a variety of protein binding partners and …
of cellular signalling. They directly interact with a variety of protein binding partners and …