Executive summary 50 years after a noble but flawed attempt to eradicate malaria in the mid-
20th century, the global malaria community is once again seriously considering eradication …

Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …

Nanoscale organization is crucial to stimulating an immune response. Using self-
assembling proteins as multimerization platforms provides a safe and immunogenic system …

Plasmodium vivax causes heavy burdens of disease across malarious regions worldwide.
Mature P. vivax asexual and transmissive gametocyte stages occur in the blood circulation …

Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load
and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for …

A reduction in the global burden of malaria over the past two decades has encouraged
efforts for regional malaria elimination. Despite the need to target all Plasmodium species …

Background Malaria elimination requires interruption of the highly efficient transmission of
Plasmodium parasites by mosquitoes. TB31F is a humanised monoclonal antibody that …

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals
carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This …

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for
malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to …