The diverse mechanisms that animals use to resist toxins

RD Tarvin, KC Pearson, TE Douglas… - Annual Review of …, 2023 - annualreviews.org
Biological toxins are entrenched within ecosystems. Thus, animals are often exposed to
such toxins, and how they adapt can be a key determinant of their evolutionary trajectories …

Unraveling the secrets: evolution of resistance mediated by membrane proteins

X Yang, M Li, ZC Jia, Y Liu, SF Wu, MX Chen… - Drug Resistance …, 2024 - Elsevier
Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields
such as medicine, agriculture, and environmental science. Understanding its complexity and …

Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies

MA Bittenbinder, J van Thiel, FC Cardoso… - Communications …, 2024 - nature.com
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …

Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans (Oxyuranus spp.) and Brown Snakes (Pseudonaja spp.)

J van Thiel, LL Alonso, J Slagboom, N Dunstan… - Toxins, 2023 - mdpi.com
Snake venoms are complex mixtures of toxins that differ on interspecific (between species)
and intraspecific (within species) levels. Whether venom variation within a group of closely …

One Size Fits All—Venomics of the Iberian Adder (Vipera seoanei, Lataste 1878) Reveals Low Levels of Venom Variation across Its Distributional Range

I Avella, M Damm, I Freitas, W Wüster, N Lucchini… - Toxins, 2023 - mdpi.com
European vipers (genus Vipera) are medically important snakes displaying considerable
venom variation, occurring at different levels in this group. The presence of intraspecific …

Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology

T Lüddecke, A Paas, RJ Harris, L Talmann… - … in bioengineering and …, 2023 - frontiersin.org
Venoms are complex chemical arsenals that have evolved independently many times in the
animal kingdom. Venoms have attracted the interest of researchers because they are an …

Sodium Channel β Subunits—An Additional Element in Animal Tetrodotoxin Resistance?

L Seneci, AS Mikheyev - International Journal of Molecular Sciences, 2024 - mdpi.com
Tetrodotoxin (TTX) is a neurotoxic molecule used by many animals for defense and/or
predation, as well as an important biomedical tool. Its ubiquity as a defensive agent has led …

Single domain antibody: Development and application in biotechnology and biopharma

T Yu, F Zheng, W He, S Muyldermans… - Immunological …, 2024 - Wiley Online Library
Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and
comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a …

[HTML][HTML] Alpha-1-B glycoprotein (A1BG) inhibits sterol-binding and export by CRISP2

O El Atab, B Gupta, Z Han, J Stribny, OA Asojo… - Journal of Biological …, 2024 - jbc.org
Proteins belonging to the CAP superfamily are present in all kingdoms of life and have been
implicated in various processes, including sperm maturation and cancer progression. They …

Illuminating the functional landscape of the dark proteome across the Animal Tree of Life through natural language processing models

GI Martínez-Redondo, I Barrios-Núñez… - bioRxiv, 2024 - biorxiv.org
Background Understanding how coding genes and their functions evolve over time is a key
aspect of evolutionary biology. Protein coding genes poorly understood or characterized at …