Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment

S AlMusawi, M Ahmed, AS Nateri - Clinical and translational …, 2021 - Wiley Online Library
Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal
fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor …

The role of cancer stem cells in colorectal cancer: from the basics to novel clinical trials

C Hervieu, N Christou, S Battu, M Mathonnet - Cancers, 2021 - mdpi.com
Simple Summary Cancer stem cells (CSCs) fuel tumor growth, metastasis and resistance to
therapy in colorectal cancer (CRC). These cells therefore represent a promising target for …

Cancer stem cell derived extracellular vesicles with self-functionalized 3D nanosensor for real-time cancer diagnosis: eliminating the roadblocks in liquid biopsy

R Haldavnekar, K Venkatakrishnan, B Tan - ACS nano, 2022 - ACS Publications
Liquid biopsy for determining the presence of cancer and the underlying tissue of origin is
crucial to overcome the limitations of existing tissue biopsy and imaging-based techniques …

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

N Li, R Babaei-Jadidi, F Lorenzi, B Spencer-Dene… - Oncogenesis, 2019 - nature.com
Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the
survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of …

Curcumin suppresses lung cancer stem cells via inhibiting Wnt/β‐catenin and sonic hedgehog pathways

JY Zhu, X Yang, Y Chen, YE Jiang… - Phytotherapy …, 2017 - Wiley Online Library
Cancer stem cells (CSCs) are highly implicated in the progression of human cancers. Thus,
targeting CSCs may be a promising strategy for cancer therapy. Wnt/β‐catenin and Sonic …

Polysaccharide matrices used in 3D in vitro cell culture systems

D Diekjürgen, DW Grainger - Biomaterials, 2017 - Elsevier
Polysaccharides comprise a diverse class of polymeric materials with a history of proven
biocompatibility and continual use as biomaterials. Recent focus on new matrices …

Autophagy inhibits cancer stemness in triple‐negative breast cancer via miR‐181a‐mediated regulation of ATG5 and/or ATG2B

JW Park, Y Kim, S Lee, CW Oh, EJ Lee… - Molecular …, 2022 - Wiley Online Library
Autophagy has a dual role in the maintenance of cancer stem cells (CSCs), but the precise
relationship between autophagy and cancer stemness requires further investigation. In this …

Current approaches in identification and isolation of cancer stem cells

M Akbarzadeh, NF Maroufi… - Journal of cellular …, 2019 - Wiley Online Library
Cancer stem cells (CSCs) are tumor cells with initiating ability, self‐renewal potential, and
intrinsic resistance to conventional therapeutics. Efficient isolation and characterization of …

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

P Su, Y Yang, G Wang, X Chen… - … journal of oncology, 2018 - spandidos-publications.com
Resistance to conventional chemotherapeutic agents, including irinotecan (CPT‑11), 5-
fluorouracil and capecitabine is a major cause for therapeutic failure in patients with …

3D bioprinted GelMA‐nanoclay hydrogels induce colorectal cancer stem cells through activating Wnt/β‐catenin signaling

Y Zhang, Z Wang, Q Hu, H Luo, B Lu, Y Gao, Z Qiao… - Small, 2022 - Wiley Online Library
Cancer stem cells (CSCs) are a rare cell population in tumors that are responsible for tumor
recurrence and metastasis. They are a priority as therapeutic targets, however, assays …