A pressing need for interrater reliability in the diagnosis of mental disorders emerged during
the mid-twentieth century, prompted in part by the development of diverse new treatments …

The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between …

Context Prefrontal cortical dysfunction is frequently reported in schizophrenia. It remains
unclear whether this represents the coincidence of several prefrontal region-and process …

The human brain has been described as a large, sparse, complex network characterized by
efficient small-world properties, which assure that the brain generates and integrates …

A dysregulation of the mesolimbic dopamine system in schizophrenia patients may lead to
aberrant attribution of incentive salience and contribute to the emergence of …

Subjects with schizophrenia are impaired at reinforcement-driven reversal learning from as
early as their first episode. The neurobiological basis of this deficit is unknown. We obtained …

To date, the diagnosis of mental disorders has been based on clinical observation,
specifically: the identification of symptoms that tend to cluster together, the timing of the …

Functional and structural brain imaging has identified neural and neurotransmitter systems
involved in schizophrenia and their link to cognitive and behavioural disturbances such as …

BackgroundFunctional imaging studies using working memory tasks have documented both
prefrontal cortex (PFC) hypo-and hyperactivation in schizophrenia. However, these studies …

After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …