Autoimmune seizures and epilepsy

C Geis, J Planagumà, M Carreño… - The Journal of …, 2019 - Am Soc Clin Investig
The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

Synaptic reshaping and neuronal outcomes in the temporal lobe epilepsy

E Ren, G Curia - International Journal of Molecular Sciences, 2021 - mdpi.com
Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy,
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …

Antiepilepticus effects of tetrahedral framework nucleic acid via inhibition of gliosis-induced downregulation of glutamine synthetase and increased AMPAR …

J Zhu, Y Yang, W Ma, Y Wang, L Chen, H Xiong… - Nano Letters, 2022 - ACS Publications
More than 15 million out of 70 million patients worldwide do not respond to available
antiepilepticus drugs (AEDs). With the emergence of nanomedicine, nanomaterials are …

Targeting ionotropic glutamate receptors in the treatment of epilepsy

R Celli, F Fornai - Current Neuropharmacology, 2021 - ingentaconnect.com
Background: A dysfunction in glutamate neurotransmission is critical for seizure. Glutamate
is the major excitatory drive in the cerebral cortex, where seizures occur. Glutamate acts via …

Anticonvulsive and neuroprotective effects of eupafolin in rats are associated with the inhibition of glutamate overexcitation and upregulation of the Wnt/β-Catenin …

WH Jean, CT Huang, JH Hsu, KM Chiu… - ACS Chemical …, 2022 - ACS Publications
Several plant compounds have been found to possess neuroactive properties. The aim of
this study was to investigate the anticonvulsant effect of eupafolin, a major active component …

Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk

JM Henley, JD Nair, R Seager, BP Yucel, G Woodhall… - …, 2021 - Elsevier
Epilepsy is caused when rhythmic neuronal network activity escapes normal control
mechanisms, resulting in seizures. There is an extensive and growing body of evidence that …

Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice

AJ Barbour, S Gourmaud, E Lancaster, X Li… - Brain, 2024 - academic.oup.com
Approximately 22% of Alzheimer's disease (AD) patients suffer from seizures, and the co-
occurrence of seizures and epileptiform activity exacerbates AD pathology and related …

Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation

A Chang, Y Chang, SJ Wang - Food & Function, 2022 - pubs.rsc.org
Rutin, a naturally derived flavonoid molecule with known neuroprotective properties, has
been demonstrated to have anticonvulsive potential, but the mechanism of this effect is still …

Febrile seizures cause a rapid depletion of calcium-permeable AMPA receptors at the synapses of principal neurons in the entorhinal cortex and hippocampus of the …

TY Postnikova, AV Griflyuk, AS Zhigulin… - International Journal of …, 2023 - mdpi.com
Febrile seizures (FSs) are a relatively common early-life condition that can cause CNS
developmental disorders, but the specific mechanisms of action of FS are poorly understood …

[HTML][HTML] The JAK-STAT signaling pathway in epilepsy

H Sun, D Ma, Y Cheng, J Li, W Zhang… - Current …, 2023 - ncbi.nlm.nih.gov
Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing
evidence that inflammatory mediators and immune cells are involved in epileptic seizures …