Osteoporosis, characterized by low bone mass and micro-architectural deterioration of bone
tissue with increased risk of fracture, can be categorized into two forms: primary and …

Obesity and osteoporosis are two of the most common chronic disorders of the 21st century.
Both are accompanied by significant morbidity. The only place in the mammalian organism …

Type 1 diabetes (T1D)–induced osteoporosis is characterized by a predominant
suppression of osteoblast number and activity, as well as increased bone marrow adiposity …

There is clear evidence that patients with type 2 diabetes mellitus (T2D) have increased
fracture risk, despite having high bone mineral density (BMD) and body mass index (BMI) …

Background & Aims We previously demonstrated that short-term oral administration of the
probiotic Lactobacillus reuteri 6475 enhanced bone density in male but not female mice. We …

Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-
canalicular pore system (LCS) buried within the mineralized matrix, which allows osteocytes …

BACKGROUND Both diabetes and osteoporosis are increasingly prevalent diseases, in part
owing to aging populations. 1, 2 According to the World Health Organization, diabetes …

Substantial evidence exists that in addition to the well-known complications of diabetes,
increased fracture risk is an important morbidity. This risk is probably due, at least in part, to …

Diabetes mellitus is associated with abnormal bone health and an increased risk of fracture
even though patients have normal or higher BMD. The mechanisms behind diabetes …

Bone loss and fractures are underrecognized complications of type 1 diabetes and are
primarily due to impaired bone formation by osteoblasts. The mechanisms leading to …