Origins and evolutionary consequences of ancient endogenous retroviruses

WE Johnson - Nature Reviews Microbiology, 2019 - nature.com
Retroviruses infect a broad range of vertebrate hosts that includes amphibians, reptiles, fish,
birds and mammals. In addition, a typical vertebrate genome contains thousands of loci …

Interplay between endogenous and exogenous human retroviruses

E Kyriakou, G Magiorkinis - Trends in Microbiology, 2023 - cell.com
In humans, retroviruses thrive more as symbionts than as parasites. Apart from the only two
modern exogenous human retroviruses (human T-cell lymphotropic and immunodeficiency …

HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression

S Srinivasachar Badarinarayan… - Nucleic Acids …, 2020 - academic.oup.com
Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements,
their role in modulating cellular immune responses remains poorly understood. Using an …

[HTML][HTML] Human endogenous retrovirus HERV-K (HML-2) RNA causes neurodegeneration through Toll-like receptors

P Dembny, AG Newman, M Singh, M Hinz… - JCI insight, 2020 - ncbi.nlm.nih.gov
Although human endogenous retroviruses (HERVs) represent a substantial proportion of the
human genome and some HERVs, such as HERV-K (HML-2), are reported to be involved in …

Human endogenous retroviruses role in cancer cell stemness

C Matteucci, E Balestrieri, A Argaw-Denboba… - Seminars in cancer …, 2018 - Elsevier
Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …

Molecular architecture and conservation of an immature human endogenous retrovirus

AS Krebs, HF Liu, Y Zhou, JS Rey, L Levintov… - Nature …, 2023 - nature.com
The human endogenous retrovirus K (HERV-K) is the most recently acquired endogenous
retrovirus in the human genome and is activated and expressed in many cancers and …

[HTML][HTML] Transactivation of Human Endogenous Retroviruses by Viruses

EF Evans, A Saraph, M Tokuyama - Viruses, 2024 - mdpi.com
Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that
are part the human genome and are normally silenced through epigenetic mechanisms …

HIV-1 remission: accelerating the path to permanent HIV-1 silencing

DE Lyons, P Kumar, NR Roan, PA Defechereux… - Viruses, 2023 - mdpi.com
Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound
competent latent and transcriptionally active reservoir cells persevere despite antiretroviral …

Viral causality of human cancer and potential roles of human endogenous retroviruses in the multi-omics era: An evolutionary epidemiology review

K Kitsou, M Iliopoulou, V Spoulou, P Lagiou… - Frontiers in …, 2021 - frontiersin.org
Being responsible for almost 12% of cancers worldwide, viruses are among the oldest
known and most prevalent oncogenic agents. The quality of the evidence for the in vivo …

[HTML][HTML] Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection

M Wang, Y Qiu, H Liu, B Liang, B Fan, X Zhou, D Liu - Virology, 2020 - Elsevier
Human endogenous retroviruses (HERVs), the remains of retroviruses infection in our
ancestors' germline cell over millions of years, take up about 8% of the human genome in …