Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms

SK Azzam, H Alsafar, AA Sajini - International journal of molecular …, 2022 - mdpi.com
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Type-specific cell line models for type-specific ovarian cancer research

MS Anglesio, KC Wiegand, N Melnyk, C Chow… - PloS one, 2013 - journals.plos.org
Background Ovarian carcinomas consist of at least five distinct diseases: high-grade serous,
low-grade serous, clear cell, endometrioid, and mucinous. Biomarker and molecular …

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation

T Song, Y Yang, H Wei, X Xie, J Lu, Q Zeng… - Nucleic acids …, 2019 - academic.oup.com
A complex and highly orchestrated gene expression program chiefly establishes the
properties that define the adipocyte phenotype, in which the vast majority of factors are …

[HTML][HTML] Exome sequencing landscape analysis in ovarian clear cell carcinoma shed light on key chromosomal regions and mutation gene networks

R Murakami, N Matsumura, JB Brown, K Higasa… - The American journal of …, 2017 - Elsevier
Previous studies have reported genome-wide mutation profile analyses in ovarian clear cell
carcinomas (OCCCs). This study aims to identify specific novel molecular alterations by …

Pathology of endometrioid and clear cell carcinoma of the ovary

O Fadare, V Parkash - Surgical pathology clinics, 2019 - surgpath.theclinics.com
This review is an appraisal of the current state of knowledge of 2 enigmatic histotypes of
ovarian carcinoma: endometrioid and clear cell carcinoma. Both show an association …

How does endometriosis lead to ovarian cancer? The molecular mechanism of endometriosis-associated ovarian cancer development

N Yachida, K Yoshihara, M Yamaguchi, K Suda… - Cancers, 2021 - mdpi.com
Simple Summary Driver gene mutations have been identified in not only various types of
endometriosis which are considered the origin of endometriosis-associated ovarian cancer …

Ovarian cancer: diagnostic, biological and prognostic aspects

B Davidson, CG Tropé - Women's Health, 2014 - journals.sagepub.com
Ovarian cancer remains the most lethal gynecologic malignancy, owing to late detection,
intrinsic and acquired chemoresistance and remarkable heterogeneity. Despite optimization …

[HTML][HTML] Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma

HN Huang, MC Lin, WC Huang, YC Chiang, KT Kuo - Modern Pathology, 2014 - Elsevier
AT-rich interactive domain 1A (ARID1A) is a subunit of switch/sucrose non-fermentable
(SWI/SNF) complex. Recently, alterations of ARID1A gene, phosphatidylinositol 3-kinase …

Identification of ZNF217, hnRNP‐K, VEGF‐A and IPO7 as targets for microRNAs that are downregulated in prostate carcinoma

J Szczyrba, E Nolte, M Hart, C Döll… - … journal of cancer, 2013 - Wiley Online Library
In primary prostate cancer (PCa), a major cause of cancer‐related death in men, the
expression of various microRNAs (miRNAs) is deregulated. We previously detected several …