Control of aldosterone secretion: a model for convergence in cellular signaling pathways
A Spat, L Hunyady - Physiological reviews, 2004 - journals.physiology.org
Spät, András, and László Hunyady. Control of Aldosterone Secretion: A Model for
Convergence in Cellular Signaling Pathways. Physiol Rev 84: 489–539, 2004; …
Convergence in Cellular Signaling Pathways. Physiol Rev 84: 489–539, 2004; …
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli
SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology
SM DeWire, JD Violin - Circulation research, 2011 - Am Heart Assoc
Drug discovery efforts targeting G-protein-coupled receptors (GPCR) have been immensely
successful in creating new cardiovascular medicines. Currently marketed GPCR drugs are …
successful in creating new cardiovascular medicines. Currently marketed GPCR drugs are …
The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System
M Colin, C Delaitre, S Foulquier, F Dupuis - Molecules, 2023 - mdpi.com
The AT1 receptor has mainly been associated with the pathological effects of the renin-
angiotensin system (RAS)(eg, hypertension, heart and kidney diseases), and constitutes a …
angiotensin system (RAS)(eg, hypertension, heart and kidney diseases), and constitutes a …
Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor
P Balakumar, G Jagadeesh - Journal of molecular …, 2014 - jme.bioscientifica.com
The renin–angiotensin system (RAS) plays an important role in the pathophysiology of
cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led …
cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led …
Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G protein-coupled receptor kinase 2
GK Dhami, PH Anborgh, LB Dale, R Sterne-Marr… - Journal of Biological …, 2002 - ASBMB
The accepted paradigm for G protein-coupled receptor kinase (GRK)-mediated
desensitization of G protein-coupled receptors involves GRK-mediated receptor …
desensitization of G protein-coupled receptors involves GRK-mediated receptor …
The Angiotensin II AT1 Receptor Structure-Activity Correlations in the Light of Rhodopsin Structure
L Oliveira, CM Costa-Neto, CR Nakaie… - Physiological …, 2007 - journals.physiology.org
The most prevalent physiological effects of ANG II, the main product of the renin-angiotensin
system, are mediated by the AT1 receptor, a rhodopsin-like AGPCR. Numerous studies of …
system, are mediated by the AT1 receptor, a rhodopsin-like AGPCR. Numerous studies of …
Mechanisms linking angiotensin II and atherogenesis
WB Strawn, CM Ferrario - Current opinion in lipidology, 2002 - journals.lww.com
Inhibition of the actions of angiotensin II serves a dual purpose: indirectly through reduction
of mechanical stress on the vascular wall, and directly by diminished stimulation for vascular …
of mechanical stress on the vascular wall, and directly by diminished stimulation for vascular …
Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits Gαq protein signaling but not ERK activation
JL Hansen, J Theilade, S Haunsø, SP Sheikh - Journal of Biological …, 2004 - ASBMB
The 7-transmembrane or G protein-coupled receptors relay signals from hormones and
sensory stimuli to multiple signaling systems at the intracellular face of the plasma …
sensory stimuli to multiple signaling systems at the intracellular face of the plasma …
Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5‐bisphosphate‐dependent modulation of Kv7 (M‐type) K+ channels
Voltage‐gated Kv7 (KCNQ) channels underlie important K+ currents in many different types
of cells, including the neuronal M current, which is thought to be modulated by muscarinic …
of cells, including the neuronal M current, which is thought to be modulated by muscarinic …