Biomaterials elicit pyroptosis enhancing cancer immunotherapy

MJ Zhang, YY Wang, LL Han, XY Liu… - Advanced Functional …, 2024 - Wiley Online Library
Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …

Roles of oxidative stress in synaptic dysfunction and neuronal cell death in Alzheimer's disease

G Plascencia-Villa, G Perry - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and
thinking skills by affecting the hippocampus and entorhinal cortex. The main …

Glutathione‐scavenging celastrol‐Cu nanoparticles induce self‐amplified cuproptosis for augmented cancer immunotherapy

S Lu, Y Li, Y Yu - Advanced Materials, 2024 - Wiley Online Library
Cuproptosis is a novel copper‐dependent programmed cell death. The efficacy of
cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a …

[HTML][HTML] Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH

L Tao, X Yang, C Ge, P Zhang, W He, X Xu, X Li… - Cell Metabolism, 2024 - cell.com
The complex etiological factors associated with metabolic dysfunction-associated fatty liver
disease (MAFLD), including perturbed iron homeostasis, and the unclear nature by which …

Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

J Tschuck, V Padmanabhan Nair, A Galhoz… - Nature …, 2024 - nature.com
The development of functional neurons is a complex orchestration of multiple signaling
pathways controlling cell proliferation and differentiation. Because the balance of …

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

J Tschuck, L Theilacker, I Rothenaigner… - Nature …, 2023 - nature.com
Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid
peroxidation. Recent research has identified many regulators that induce or inhibit …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis

AE Culver-Cochran, A Hassan, K Hueneman… - Nature …, 2024 - nature.com
Acute myeloid leukemia (AML) is a deadly hematopoietic malignancy. Although many
patients achieve complete remission with standard induction therapy, a combination of …

Targeting immunogenic cell stress and death for cancer therapy

L Galluzzi, E Guilbaud, D Schmidt, G Kroemer… - Nature Reviews Drug …, 2024 - nature.com
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …

Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication

H Wang, T Wang, S Yan, J Tang, Y Zhang, L Wang… - Molecular Cancer, 2024 - Springer
In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in
tumor initiation and progression, shaped by complex interactions between cancer cells and …