The role of glial autophagy in Alzheimer's disease

A Litwiniuk, GR Juszczak, AM Stankiewicz… - Molecular …, 2023 - nature.com
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

Induced pluripotent stem cells and their applications in amyotrophic lateral sclerosis

H Du, Z Huo, Y Chen, Z Zhao, F Meng, X Wang, S Liu… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Microglia and astrocytes in amyotrophic lateral sclerosis: disease-associated states, pathological roles, and therapeutic potential

J You, MMM Youssef, JR Santos, J Lee, J Park - Biology, 2023 - mdpi.com
Simple Summary Amyotrophic lateral sclerosis (ALS) is a disease characterized by the
death of motor neurons that results in progressive muscle weakness and paralysis …

Why should we care about astrocytes in a motor neuron disease?

K Stoklund Dittlau, L Van Den Bosch - Frontiers in Molecular …, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults,
causing progressive degeneration of motor neurons, which results in muscle atrophy …

Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity

Y Li, M Que, X Wang, G Zhan, Z Zhou, X Luo, S Li - Biomedicines, 2023 - mdpi.com
Astrocytes, the most abundant cells in the brain, are integral to sleep regulation. In the
context of a healthy neural environment, these glial cells exert a profound influence on the …

Role of autophagy mediated by AMPK/DDiT4/mTOR Axis in HT22 cells under oxygen and glucose deprivation/reoxygenation

Y Zhang, L Liu, X Hou, Z Zhang, X Zhou, W Gao - ACS omega, 2023 - ACS Publications
Background: cerebral ischemia/reperfusion (I/R) injury is an important complication of
ischemic stroke, and autophagy is one of the mechanisms of it. In this study, we aimed to …

Combined transplantation of hiPSC-NSC and hMSC ameliorated neuroinflammation and promoted neuroregeneration in acute spinal cord injury

X Du, D Kong, R Guo, B Liu, J He, J Zhang… - Stem Cell Research & …, 2024 - Springer
Background Spinal cord injury (SCI) is a serious clinical condition that has pathological
changes such as increased neuroinflammation and nerve tissue damage, which eventually …

Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic Therapies

AR Dashtmian, FB Darvishi, WD Arnold - Cells, 2024 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is a group of sporadic and genetic neurodegenerative
disorders that result in losses of upper and lower motor neurons. Treatment of ALS is limited …

Identification of the abnormalities in astrocytic functions as potential drug targets for neurodegenerative disease

V Syvänen, J Koistinaho, Š Lehtonen - Expert opinion on drug …, 2024 - Taylor & Francis
Introduction Historically, astrocytes were seen primarily as a supportive cell population
within the brain; with neurodegenerative disease research focusing exclusively on …

Modeling of TDP-43 proteinopathy by chronic oxidative stress identifies rapamycin as beneficial in ALS patient-derived 2D and 3D iPSC models

V Casiraghi, MN Sorce, S Santangelo, S Invernizzi… - Experimental …, 2025 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder
characterized neuropathologically by TDP-43 proteinopathy with loss of TDP-43 nuclear …