Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1)
exhibit incretin activity, meaning that they potentiate glucose-dependent insulin secretion …

Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …

Background Upper small intestinal dietary lipids activate a gut-brain axis regulating energy
homeostasis. The prebiotic, oligofructose (OFS) improves body weight and adiposity during …

Survival under selective pressure is driven by the ability of our brain to use sensory
information to our advantage to control physiological needs. To that end, neural circuits …

Dietary fiber improves metabolic health, but host-encoded mechanisms for digesting fibrous
polysaccharides are unclear. In this work, we describe a mammalian adaptation to dietary …

The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …

Remedies for the treatment of obesity date to Hippocrates, when patients with obesity were
directed to “reduce food and avoid drinking to fullness” and begin “running during the night.” …

Understanding the neural processes governing the human gut-brain connection has been
challenging due to the inaccessibility of the body's interior. Here, we investigated neural …

While food is essential for survival, it can also cause a variety of harmful effects, ranging from
intolerance to specific nutrients to celiac disease and food allergies. In addition to nutrients …

Interoception plays an important role in homeostatic regulation of energy intake and
metabolism. Major interoceptive pathways include gut-to-brain and adipose tissue-to brain …