Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …

Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of
kynurenic acid, anthranilic acid and 3-hydroxykynurenine (3-HK). Under physiological …

This paper reviews the body of evidence that not only tryptophan and consequent 5-HT
depletion, but also induction of indoleamine 2, 3-dioxygenase (IDO) and the detrimental …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA
receptor antagonist. Here, interactions between KYNA and the nicotinic system in the brain …

Background: Metabolites of the kynurenine pathway of tryptophan degradation may play a
role in the pathogenesis of several human brain diseases. One of the key metabolites in this …

Aims The family of kynurenine pathway (KP) metabolites includes compounds produced
along two arms of the path and acting in clearly opposite ways. The equilibrium between …

Understanding the neurochemical basis for cognitive function is one of the major goals of
neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range …

Schizophrenia is characterised by hallucinations, delusions, depression-like so-called
negative symptoms, cognitive dysfunction, impaired neurodevelopment and …

The synthesis of NAD (or NADP) from tryptophan involves a series of enzymes and the
formation of a number of intermediates which are collectively calledkynurenines.'In the late …