Drug discovery and development involve the utilization of in vitro and in vivo experimental
models. Different models, ranging from test tube experiments to cell cultures, animals …

Introduction: HepaRG is a unique cell line showing a great plasticity, which differentiates to
both canaliculae-like and hepatocyte-like cells. The long-term stability of key cell functions …

The HepaRG cell line is the first human cell line able to differentiate in vitro into mature
hepatocyte-like cells. Our main objective within the framework of the EEC-LIINTOP project …

Purpose To provide a definitive assessment of prediction of in vivo CL int from human liver in
vitro systems for assessment of typical underprediction. Methods A database of published …

The liver has the unique capacity to regenerate in response to a damaging event. Liver
regeneration is hereby largely driven by hepatocyte proliferation, which in turn relies on cell …

The pharmacokinetic and safety assessment of drug candidates is becoming increasingly
dependent upon in vitro models of hepatic metabolism and toxicity. Predominant among …

Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription
factors that control the expression of a broad array of genes involved not only in transcellular …

Drug metabolism is a major determinant of drug concentrations in the body. Drug-drug
interactions (DDIs) caused by the co-administration of multiple drugs can lead to alteration in …

Better prediction of safety risk and understanding of mechanism of action of drug candidates
remain a major challenge in order to prevent late stage attrition. Continuous efforts are made …