Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid
metabolism and a maladaptive immune response driven by the accumulation of cholesterol …

Abstract Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), a component of
Gram-negative bacteria to induce production of pro-inflammatory mediators aiming at …

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

Signal transduction by the Toll-like receptors (TLRs) is central to host defence against many
pathogenic microorganisms and also underlies a large burden of human disease. Thus, the …