Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by
hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT …

To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

A link between metabolic syndrome (MetS) and lung diseases has been observed in several
cross-sectional and longitudinal studies. This syndrome has been identified as an …

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with
important roles in lifespan. They promote growth, anabolic actions, and body maintenance …

In this review, we analyze the effects of growth hormone on a number of tissues and organs
and its putative role in the longitudinal growth of an organism. We conclude that the …

Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …

Immune function is an energetically costly physiological activity that potentially diverts
calories away from less immediately essential life tasks. Among developing organisms, the …