Keratoconus diagnosis and treatment: recent advances and future directions

AD Bui, A Truong, ND Pasricha… - Clinical …, 2023 - Taylor & Francis
Keratoconus is a disorder characterized by progressive corneal thinning and steepening
that may result in significant visual impairment secondary to high astigmatism, corneal …

Biochemical markers and alterations in keratoconus

R Shetty, S D'Souza, P Khamar, A Ghosh… - The Asia-Pacific …, 2020 - journals.lww.com
Keratoconus (KC) is a corneal ectatic condition characterized by focal structural changes,
resulting in progressive thinning, biomechanical weakening, and steeping of the cornea that …

Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile

S D'Souza, AP Nair, GR Sahu, T Vaidya, R Shetty… - Scientific Reports, 2021 - nature.com
Inflammatory factors have been considered to contribute to keratoconus (KC) pathogenesis.
This study aims to determine the immune cells subsets and soluble inflammatory factor …

Corneal regeneration using gene therapy approaches

S Sarkar, P Panikker, S D'Souza, R Shetty, RR Mohan… - Cells, 2023 - mdpi.com
One of the most remarkable advancements in medical treatments of corneal diseases in
recent decades has been corneal transplantation. However, corneal transplants, including …

[HTML][HTML] Proteins: Neglected active ingredients in edible bird's nest

M Yuan, X Lin, D Wang, J Dai - Chinese Herbal Medicines, 2023 - Elsevier
Edible bird's nest (EBN) is a kind of natural invigorant with a long history of consumption in
Asia, especially in China. EBN is formed by mixing the saliva of swiftlets (Aerodramus) with …

LOXL3 function beyond amino oxidase and role in pathologies, including cancer

TS Laurentino, RS Soares, SKN Marie… - International journal of …, 2019 - mdpi.com
Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the
crosslinking of collagen and elastin in the extracellular matrix. LOXL3 belongs to a family …

[HTML][HTML] Potential underlying genetic associations between keratoconus and diabetes mellitus

KM Ates, AJ Estes, Y Liu - Advances in ophthalmology practice and …, 2021 - Elsevier
Background Keratoconus (KC) is the most common ectatic corneal disease, characterized
by significantly localized thinning of the corneal stroma. Genetic, environmental, hormonal …

[HTML][HTML] Comprehensive analysis identified the circadian clock and global circadian gene expression in human corneal endothelial cells

H Nakai, Y Tsuchiya, N Koike, T Asano… - … & Visual Science, 2022 - tvst.arvojournals.org
Purpose: To investigate circadian clock oscillation and circadian global gene expression in
cultured human corneal endothelial cells (cHCECs) to elucidate and assess the potential …

Systematically Displaying the Pathogenesis of Keratoconus via Multi-Level Related Gene Enrichment-Based Review

XD Hao, H Gao, WH Xu, C Shan, Y Liu, ZX Zhou… - Frontiers in …, 2022 - frontiersin.org
Keratoconus (KC) is an etiologically heterogeneous corneal ectatic disorder. To
systematically display the pathogenesis of keratoconus (KC), this study reviewed all the …

Comparative analysis of the morphological and biomechanical properties of normal cornea and keratoconus at different stages

Y Wu, LL Guo, L Tian, ZQ Xu, Q Li, J Hu… - International …, 2021 - Springer
Purpose To compare the morphological and biomechanical properties of normal cornea and
keratoconus at different stages. Methods A total of 408 patients (517 eyes) with keratoconus …