Mental health researchers and clinicians have long sought answers to the question “What
works for whom?” The goal of precision medicine is to provide evidence-based answers to …

Objective: Evidence-based practice involves the consideration of efficacy and effectiveness,
clinical expertise, and patient preference in treatment selection. However, patient preference …

Background Non‐specific low back pain is a common, potentially disabling condition usually
treated with self‐care and non‐prescription medication. For chronic low back pain, current …

Pragmatic trials are important for informing routine clinical practice, but current designs have
shortcomings. Clare Relton and colleagues outline the new “cohort multiple randomised …

Objective To assess how initial severity of depression affects the benefit derived from low
intensity interventions for depression. Design Meta-analysis of individual patient data from …

Mindfulness has been described as a practice of learning to focus attention on moment-
bymoment experience with an attitude of curiosity, openness, and acceptance. Mindfulness …

International Headache Society Clinical Trials Subcommittee members: Peer Tfelt-Hansen
(chairman)(Denmark) 1, Julio Pascual (vice-chairman)(Spain) 2, Nabih Ramadan (vice …

Mindfulness-based stress reduction (MBSR) is a structured 8-week group program teaching
mindfulness meditation and mindful yoga exercises. MBSR aims to help participants …

The purpose of this review was to systematically review the published research on the effect
of self-compassion interventions on health behaviors. A self-regulation intervention was …

Importance Current evidence suggests that nonoperative management of uncomplicated
appendicitis is safe, but overall effectiveness is determined by combining medical outcomes …