The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Biomedical and biochemical applications of self-assembled metallacycles and metallacages

TR Cook, V Vajpayee, MH Lee, PJ Stang… - Accounts of chemical …, 2013 - ACS Publications
Metal ions and metal complexes with organic molecules are ubiquitous in nature. Bulk metal
ions of Na, K, Mg, and Ca constitute as much as 1% of human body weight. The remaining …

Targeted and multifunctional arene ruthenium chemotherapeutics

GS Smith, B Therrien - Dalton transactions, 2011 - pubs.rsc.org
The introduction of multifunctionalities for tumour targeting is becoming a popular strategy
toward the development of new therapeutic agents. In particular, the multifaceted potential of …

Biomedical applications of multinuclear Pt (II)/Ru (II)/Ir (III) metallo-supramolecular assemblies for intensive cancer therapy

X Li, X Zhao, W Wang, Z Shi, Y Zhang, Q Tian… - Coordination Chemistry …, 2023 - Elsevier
The development of highly efficient and minimally toxic agents with targeting abilities toward
tumor tissues is an ongoing area of research in the fight against cancer. Different from the …

Antiproliferative activity of chelating N, O-and N, N-ruthenium (II) arene functionalised poly (propyleneimine) dendrimer scaffolds

P Govender, AK Renfrew, CM Clavel, PJ Dyson… - Dalton …, 2011 - pubs.rsc.org
Chelating neutral (N, O) and cationic (N, N) first-and second-generation ruthenium (II) arene
metallodendrimers based on poly (propyleneimine) dendrimer scaffolds were obtained from …

Biomedical applications of metal organic polygons and polyhedra (MOPs)

SK Samanta, L Isaacs - Coordination chemistry reviews, 2020 - Elsevier
Since the discovery and structural characterization of metal organic polygons and polyhedra
(MOPs), scientists have explored their potential in various applications like catalysis …

Transporting and Shielding Photosensitisers by Using Water‐Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy

B Therrien - Chemistry–A European Journal, 2013 - Wiley Online Library
Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this
Concept article a strategy to overcome this limitation is described, in which the …

Drug delivery by water-soluble organometallic cages

B Therrien - Chemistry of Nanocontainers, 2012 - Springer
Until recently, organometallic derivatives were generally viewed as moisture-and air-
sensitive compounds, and consequently very challenging to synthesise and very demanding …

Biologically active [Pd 2 L 4] 4+ quadruply-stranded helicates: stability and cytotoxicity

SM McNeill, D Preston, JEM Lewis, A Robert… - Dalton …, 2015 - pubs.rsc.org
There is emerging interest in the anti-proliferative effects of metallosupramolecular systems
due to the different size and shape of these metallo-architectures compared to traditional …

Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

P Štarha - Coordination Chemistry Reviews, 2021 - Elsevier
The development of multinuclear homometallic biologically active complexes is attractive for
modern bioinorganic chemistry, because this concept offers a multiplication of the …