Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Physical activity and several pharmacological approaches individually combat age-
associated conditions and extend healthy longevity in model systems. It is tantalizing to …

Skeletal muscle mass is a very plastic characteristic of skeletal muscle and is regulated by
signaling pathways that control the balance between anabolic and catabolic processes. The …

Understanding the intricate mechanisms governing the cellular response to resistance
exercise is paramount for promoting healthy aging. This narrative review explored the age …

Oxidative stress and inflammation are associated with skeletal muscle function decline with
ageing or disease or inadequate exercise and/or poor diet. Paradoxically, reactive oxygen …

Aim To investigate systemic regulators of the cancer‐associated cachexia syndrome (CACS)
in a pre‐clinical model for lung cancer with the goal to identify therapeutic targets for tissue …

Ground-breaking discoveries have established 5′-AMP-activated protein kinase (AMPK) as
a central sensor of metabolic stress in cells and tissues. AMPK is activated through cellular …

Resistance exercise training (RET) attenuates age-related muscle and strength loss
('sarcopenia'). However, compared with machine-based RET, the efficacy of cost-effective …

As a result of advances in medical treatments and associated policy over the last century, life
expectancy has risen substantially and continues to increase globally. However, the …

Murine exercise models are developed to study the molecular and cellular mechanisms
regulating muscle mass. A progressive weighted wheel running model, named 'PoWeR' …