Enhanced and deregulated expression of N-MYC, a member of the MYC family of
transcription factors, drives the development of multiple tumors, including tumors of the …

Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …

Rationale: Synergic reprogramming of metabolic dominates neuroblastoma (NB)
progression. It is of great clinical implications to develop an individualized risk …

Diffuse high-grade gliomas (HGGs) of childhood are a devastating spectrum of disease with
no effective cures. The two-year survival for paediatric HGG ranges from 30%, for tumours …

Neuroblastoma is an embryonal malignancy that commonly affects young children and is
remarkably heterogenous in its malignant potential. Recently, the genetic basis of …

Spinal ependymal tumors form a histologically and molecularly heterogeneous group of
tumors with generally good prognosis. However, their treatment can be challenging if …

Myc family proteins promote cancer by inducing widespread changes in gene expression.
Their rapid turnover by the ubiquitin–proteasome pathway is regulated through …

Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN
is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous …

Purpose: Targeting BET proteins was previously shown to have specific antitumoral efficacy
against MYCN-amplified neuroblastoma. We here assess the therapeutic efficacy of the BET …

Purpose In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations.
We investigated the potential role of ALK mutations in neuroblastoma clonal evolution …