The T‐box gene family, encoding related DNA‐binding transcriptional regulators, plays an
essential role in controlling many aspects of embryogenesis in a wide variety of organisms …

The modular components, or subcircuits, of developmental gene regulatory networks
(GRNs) execute specific developmental functions, such as the specification of cell identity …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

We present here an analysis of cardiovascular and pharyngeal arch development in mouse
embryos hypomorphic for Fgf8. Previously, we have described the generation of Fgf8 …

Tbx20 is a member of the T-box transcription factor family expressed in the forming hearts of
vertebrate and invertebrate embryos. We report here analysis of Tbx20 expression during …

Tbx1 haploinsufficiency causes aortic arch abnormalities in mice because of early growth
and remodeling defects of the fourth pharyngeal arch arteries. The function of Tbx1 in the …

The T box transcription factor Brachyury is essential for the formation of the posterior body in
all vertebrates, although its critical transcriptional targets have remained elusive. Loss-of …

The basic‐helix‐loop‐helix‐leucine zipper (bHLHZip) proteins Myc, Mad and Mnt are part of
a transcription activation/repression system involved in the regulation of cell proliferation …

A major gap in our knowledge of development is how the growth and identity of tissues and
organs are linked during embryogenesis. The vertebrate limb is one of the best models to …

The T-box gene tbx5 is expressed in the developing heart, forelimb, eye, and liver in
vertebrate embryos during critical stages of morphogenesis and patterning. In humans …