Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways
I Batinic-Haberle, A Tovmasyan… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …
Cerium oxide nanoparticles scavenge nitric oxide radical (˙ NO)
In this study we have obtained evidence that cerium oxide nanoparticles (CeO2 NPs) are
able to scavenge nitric oxide radical. Surprisingly, this activity is present in CeO2 NPs with a …
able to scavenge nitric oxide radical. Surprisingly, this activity is present in CeO2 NPs with a …
Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury
I Batinic-Haberle, A Tovmasyan… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
[HTML][HTML] An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins–from superoxide dismutation to H2O2-driven pathways
Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …
Potential Therapeutic Applications of MnSODs and SOD‐Mimetics
R Bonetta - Chemistry–A European Journal, 2018 - Wiley Online Library
Natural as well as synthetic antioxidants are constantly being investigated for their efficiency
in combatting the effects of oxidative stress, which appears to be the responsible cause of …
in combatting the effects of oxidative stress, which appears to be the responsible cause of …
Redox modulation of HMGB1-related signaling
C Janko, M Filipović, LE Munoz, C Schorn… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: In the cells' nuclei, high-mobility group box protein 1 (HMGB1) is a nonhistone
chromatin-binding protein involved in the regulation of transcription. Extracellularly, HMGB1 …
chromatin-binding protein involved in the regulation of transcription. Extracellularly, HMGB1 …
Rationally designed mimics of antioxidant manganoenzymes: Role of structural features in the quest for catalysts with catalase and superoxide dismutase activity
S Signorella, C Palopoli, G Ledesma - Coordination Chemistry Reviews, 2018 - Elsevier
Manganese catalases (MnCAT) and superoxide dismutases (MnSOD) deplete hydrogen
peroxide and superoxide in cells through a ping-pong mechanism involving cyclic oxidation …
peroxide and superoxide in cells through a ping-pong mechanism involving cyclic oxidation …
Manganese complexes displaying superoxide dismutase activity: a balance between different factors
O Iranzo - Bioorganic chemistry, 2011 - Elsevier
Superoxide radicals are one of the most toxic reactive oxygen species and its damaging
effects lead to a variety of detrimental health conditions including cardiovascular diseases …
effects lead to a variety of detrimental health conditions including cardiovascular diseases …
Coordination complexes of 15-membered pentadentate aza, oxoaza and thiaaza Schiff base macrocycles “Old Complexes Offer New Attractions”
EL Gavey, M Pilkington - Coordination Chemistry Reviews, 2015 - Elsevier
Two classes of complexes of 15-membered Schiff base macrocycles with a pentadentate (N
3 X 2) cavity (where X= O, N, S) prepared via a metal templated condensation reaction …
3 X 2) cavity (where X= O, N, S) prepared via a metal templated condensation reaction …