Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Neurotransmitter modulation by the gut microbiota

P Strandwitz - Brain research, 2018 - Elsevier
The gut microbiota–the trillions of bacteria that reside within the gastrointestinal tract–has
been found to not only be an essential component immune and metabolic health, but also …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

General pathways of pain sensation and the major neurotransmitters involved in pain regulation

MF Yam, YC Loh, CS Tan, S Khadijah Adam… - International journal of …, 2018 - mdpi.com
Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

Control of brain development, function, and behavior by the microbiome

TR Sampson, SK Mazmanian - Cell host & microbe, 2015 - cell.com
Animals share an intimate and life-long partnership with a myriad of resident microbial
species, collectively referred to as the microbiota. Symbiotic microbes have been shown to …

Minireview: gut microbiota: the neglected endocrine organ

G Clarke, RM Stilling, PJ Kennedy… - Molecular …, 2014 - academic.oup.com
The concept that the gut microbiota serves as a virtual endocrine organ arises from a
number of important observations. Evidence for a direct role arises from its metabolic …

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

SB Chidambaram, MM Essa, AG Rathipriya… - Pharmacology & …, 2022 - Elsevier
The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

[HTML][HTML] Gut microbial metabolites in depression: understanding the biochemical mechanisms

G Caspani, S Kennedy, JA Foster, J Swann - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Gastrointestinal and central function are intrinsically connected by the gut microbiota, an
ecosystem that has co-evolved with the host to expand its biotransformational capabilities …

The neuro-endocrinological role of microbial glutamate and GABA signaling

R Mazzoli, E Pessione - Frontiers in microbiology, 2016 - frontiersin.org
Gut microbiota provides the host with multiple functions (eg, by contributing to food
digestion, vitamin supplementation, and defense against pathogenic strains) and interacts …

Bioactive molecules released in food by lactic acid bacteria: Encrypted peptides and biogenic amines

E Pessione, S Cirrincione - Frontiers in microbiology, 2016 - frontiersin.org
Lactic acid bacteria (LAB) can produce a huge amount of bioactive compounds. Since their
elective habitat is food, especially dairy but also vegetal food, it is frequent to find bioactive …