Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …

By ecologically interacting with various biotic and abiotic agents acting in soil ecosystems,
highly diverse soil microorganisms establish complex and stable assemblages and survive …

Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in
producing a wide range of natural products with diverse biological functions, including …

Microbial secondary metabolites have long been considered as potential sources of lead
compounds for medicinal use due to their rich chemical diversity and extensive biological …

Aromatic polyketides biosynthesized by microorganisms are a prominent class of natural
products widely used in clinical treatments. Although genome mining approaches have …

Gram-positive Streptomyces bacteria can produce valuable secondary metabolites.
Streptomyces genomes include huge unknown silent natural product (NP) biosynthetic gene …

Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including
bacterial isolation, fermentation, metabolite identification and structure elucidation have …

Filamentous microorganisms are potent sources of bioactive secondary metabolites, the
molecules formed in response to complex environmental signals. The chemical diversity …

Antibiotics found in and inspired by nature are life-saving cures for bacterial infections and
have enabled modern medicine. However, the rise in resistance necessitates the discovery …

Microbial secondary metabolites (SMs) have long been viewed as a significant source of
novel pharmaceutical and agrochemical molecules. With the increasing availability of …