Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder

N Eissa, M Al-Houqani, A Sadeq, SK Ojha… - Frontiers in …, 2018 - frontiersin.org
Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics

LR Hirschfeld, SL Risacher, K Nho… - Translational …, 2022 - Springer
This literature review investigates the significant overlap between myelin-repair signaling
pathways and pathways known to contribute to hallmark pathologies of Alzheimer's disease …

Targeting microglia in neuroinflammation: H3 receptor antagonists as a novel therapeutic approach for Alzheimer's disease, Parkinson's disease, and autism spectrum …

SD Thomas, S Abdalla, N Eissa, A Akour, NK Jha… - Pharmaceuticals, 2024 - mdpi.com
Histamine performs dual roles as an immune regulator and a neurotransmitter in the
mammalian brain. The histaminergic system plays a vital role in the regulation of …

The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism

N Eissa, P Jayaprakash, S Azimullah, SK Ojha… - Scientific reports, 2018 - nature.com
Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
impairment in social communication and restricted/repetitive behavior patterns or interests …

Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer's disease

J Wang, B Liu, Y Xu, M Yang, C Wang, M Song… - Aging …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is an age‐related neurodegenerative disease, and the imbalance
between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis …

The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in …

N Eissa, S Azimullah, P Jayaprakash… - Chemico-biological …, 2019 - Elsevier
Postnatal exposure to valproic acid (VPA) in rodents induces autism-like neurobehavioral
defects which are comparable to the motor and cognitive deficits observed in humans with …

Brain histamine modulates recognition memory: possible implications in major cognitive disorders

G Provensi, A Costa, I Izquierdo… - British journal of …, 2020 - Wiley Online Library
Several behavioural tests have been developed to study and measure emotionally charged
or emotionally neutral memories and how these may be affected by pharmacological, dietary …

Revisiting preclinical observations of several histamine H3 receptor antagonists/inverse agonists in cognitive impairment, anxiety, depression, and sleep–wake cycle …

M Alhusaini, N Eissa, AK Saad, R Beiram… - Frontiers in …, 2022 - frontiersin.org
A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish

ACVV Giacomini, BW Bueno… - Journal of …, 2020 - journals.sagepub.com
Background: A potent acetylcholinesterase inhibitor, donepezil is a cognitive enhancer
clinically used to treat neurodegenerative diseases. However, its complete pharmacological …

The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid …

N Eissa, S Azimullah, P Jayaprakash… - International journal of …, 2020 - mdpi.com
The histamine H3 receptor (H3R) functions as auto-and hetero-receptors, regulating the
release of brain histamine (HA) and acetylcholine (ACh), respectively. The enzyme …