Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent
years has the complexity of the transcriptome started to be elucidated. However, its …

Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and
therefore have significant potential to treat genetic disorders, infectious diseases, and …

Simple Summary Circular RNAs (circRNAs) belong to a new class of non-coding RNAs
implicated in cellular physiological functions but also in the evolution of various human …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

Discovered two decades ago, Piwi-interacting RNAs (piRNAs) play critical roles in gene
regulation, transposon element repression, and antiviral defense. Dysregulation of piRNAs …

Targeting non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-
coding RNAs (lncRNAs), has recently emerged as a promising strategy for treating …

The explosion of research on non-coding RNAs (ncRNAs) in the past few decades has
transformed the original notion of regarding such RNAs as 'transcriptional noise'[1, 2] before …

The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …

The small nucleolar RNA host genes (SNHGs) are a group of genes that can be transcript
into long non-coding RNA SNHG (lncSNHG) and further processed into small nucleolar …

Abstract Background Small RNAs (sRNAs), a heterogenous group of non-coding RNAs, are
emerging as promising molecules for cancer patient risk stratification and as players in …