Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …

In 1979, the first chromosome alteration associated with familial cancer was reported. Five
years later, a fragile site was observed in the same chromosome region. The product of the …

HIT (histidine triad) proteins, named for a motif related to the sequence HϕHϕHϕϕ (ϕ, a
hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases …

Loss of expression of the Fhit protein is often associated with the development of many
human epithelial cancers, including lung and cervical carcinomas. Restoration of Fhit …

Mice carrying one inactivated Fhit allele (Fhit+/− mice) are highly susceptible to tumor
induction by N-nitrosomethylbenzylamine, with 100% of Fhit+/− mice exhibiting tumors of the …

Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts
as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+ …

Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity,
are among the most common features of human tumours. The short arm of human …

Although mutations in the parkin gene are frequently associated with familial Parkinsonism,
emerging evidence suggests that parkin also plays a role in cancers as a putative tumor …

Pontin and Reptin previously were identified as nuclear β-catenin interaction partners that
antagonistically modulate β-catenin transcriptional activity. In this study, Hint1/PKCI, a …

Expression of the WWOX gene, encompassing the common chromosome fragile site
FRA16D, is altered in a large fraction of cancers of various types, including prostate cancer …