TDP-43 pathology: from noxious assembly to therapeutic removal
Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
Connecting TDP-43 pathology with neuropathy
JR Klim, G Pintacuda, LA Nash, IG San Juan… - Trends in …, 2021 - cell.com
Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-
binding protein, is a primary component of insoluble aggregates associated with several …
binding protein, is a primary component of insoluble aggregates associated with several …
Nanomedicine based strategies for oligonucleotide traversion across the blood–brain barrier
Neurological disorders are considered the most prominent cause of disability worldwide.
The major hurdle in the management of neurological disorders is the existence of the blood …
The major hurdle in the management of neurological disorders is the existence of the blood …
From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
Amyotrophic lateral sclerosis (ALS) and Frontotemporal Degeneration (FTD) are
neurodegenerative disorders, related by deterioration of motor and cognitive functions and …
neurodegenerative disorders, related by deterioration of motor and cognitive functions and …
Delivery of genome editing tools: A promising strategy for HPV-related cervical malignancy therapy
Introduction Persistent high-risk human papillomavirus infection is the main cause of various
types of cancer especially cervical cancer. The E6 and E7 oncoproteins of HPV play critical …
types of cancer especially cervical cancer. The E6 and E7 oncoproteins of HPV play critical …
General and specific cytotoxicity of chimeric antisense oligonucleotides in bacterial cells and human cell lines
KB Popova, R Penchovsky - Antibiotics, 2024 - mdpi.com
In the last two decades, antisense oligonucleotide technology has emerged as a promising
approach to tackling various healthcare issues and diseases, such as antimicrobial …
approach to tackling various healthcare issues and diseases, such as antimicrobial …
A small molecule exploits hidden structural features within the RNA repeat expansion that causes c9ALS/FTD and rescues pathological hallmarks
A Ursu, JT Baisden, JA Bush, A Taghavi… - ACS chemical …, 2021 - ACS Publications
The hexanucleotide repeat expansion GGGGCC [r (G4C2) exp] within intron 1 of C9orf72
causes genetically defined amyotrophic lateral sclerosis and frontotemporal dementia …
causes genetically defined amyotrophic lateral sclerosis and frontotemporal dementia …
Pervasive role of the long noncoding RNA DNM3OS in development and diseases
S Fellah, R Larrue, M Truchi, G Vassaux… - Wiley …, 2023 - Wiley Online Library
Thousands of unique noncoding RNAs (ncRNAs) are expressed in human cells, some are
tissue or cell type specific whereas others are considered as house‐keeping molecules …
tissue or cell type specific whereas others are considered as house‐keeping molecules …
Transcriptomics and RNA-based therapeutics as potential approaches to manage SARS-CoV-2 infection
C Arriaga-Canon, L Contreras-Espinosa… - International Journal of …, 2022 - mdpi.com
SARS-CoV-2 is a coronavirus family member that appeared in China in December 2019 and
caused the disease called COVID-19, which was declared a pandemic in 2020 by the World …
caused the disease called COVID-19, which was declared a pandemic in 2020 by the World …
Modern approaches in gene therapy of motor neuron diseases
M Zakharova - Medicinal Research Reviews, 2021 - Wiley Online Library
Motor neuron disorders are a group of neurodegenerative diseases characterized by muscle
weakness, loss of ambulation, respiratory insufficiency, leading to an early death. Spinal …
weakness, loss of ambulation, respiratory insufficiency, leading to an early death. Spinal …