Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

L Ferrazzano, M Catani, A Cavazzini, G Martelli… - Green …, 2022 - pubs.rsc.org
Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

Liquid-phase peptide synthesis (LPPS): a third wave for the preparation of peptides

A Sharma, A Kumar, BG De La Torre… - Chemical …, 2022 - ACS Publications
Since the last century, peptides have gained wide acceptance as drugs, with almost 100
already in the market and a large number in the pipeline. In this context, peptide synthesis …

Cysteine protecting groups: applications in peptide and protein science

RJ Spears, C McMahon, V Chudasama - Chemical Society Reviews, 2021 - pubs.rsc.org
Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide
and protein chemistry over the last several decades. Increasingly sophisticated strategies for …

Greening the synthesis of peptide therapeutics: an industrial perspective

V Martin, PHG Egelund, H Johansson… - RSC …, 2020 - pubs.rsc.org
Solid-phase peptide synthesis (SPPS) is generally the method of choice for the chemical
synthesis of peptides, allowing routine synthesis of virtually any type of peptide sequence …

Cyanobacteria and eukaryotic microalgae as emerging sources of antibacterial peptides

V Rojas, L Rivas, C Cárdenas, F Guzmán - Molecules, 2020 - mdpi.com
Cyanobacteria and microalgae are oxygen-producing photosynthetic unicellular organisms
encompassing a great diversity of species, which are able to grow under all types of extreme …

Cyclic peptides in pipeline: what future for these great molecules?

L Costa, E Sousa, C Fernandes - Pharmaceuticals, 2023 - mdpi.com
Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

Inverse peptide synthesis using transient protected amino acids

T Liu, Z Peng, M Lai, L Hu, J Zhao - Journal of the American …, 2024 - ACS Publications
Peptide therapeutics have experienced a rapid resurgence over the past three decades.
While a few peptide drugs are biologically produced, most are manufactured via chemical …

[HTML][HTML] Lipopeptides development in cosmetics and pharmaceutical applications: a comprehensive review

M Pilz, P Cavelius, F Qoura, D Awad, T Brück - Biotechnology Advances, 2023 - Elsevier
Lipopeptides are surface active, natural products of bacteria, fungi and green-blue algae
origin, having diverse structures and functionalities. In analogy, a number of chemical …

Harnessing polarity and viscosity to identify green binary solvent mixtures as viable alternatives to DMF in solid-phase peptide synthesis

V Martin, S Jadhav, PHG Egelund, R Liffert… - Green …, 2021 - pubs.rsc.org
Solid-phase peptide synthesis (SPPS) enables routine synthesis of virtually any type of
peptide sequence and is the preferred method for peptide synthesis in academia and the …

Marine cyclic peptides: Antimicrobial activity and synthetic strategies

R Ribeiro, E Pinto, C Fernandes, E Sousa - Marine Drugs, 2022 - mdpi.com
Oceans are a rich source of structurally unique bioactive compounds from the perspective of
potential therapeutic agents. Marine peptides are a particularly interesting group of …