Understanding mechanisms of antioxidant action in health and disease

B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …

Roles of heme oxygenase-1 in neuroinflammation and brain disorders

YH Wu, HL Hsieh - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous
system under stress conditions. HO degrades heme to carbon monoxide, iron, and …

Neurodegeneration in multiple sclerosis: the role of Nrf2-dependent pathways

PP Maldonado, C Guevara, MA Olesen, JA Orellana… - Antioxidants, 2022 - mdpi.com
Multiple sclerosis (MS) encompasses a chronic, irreversible, and predominantly immune-
mediated disease of the central nervous system that leads to axonal degeneration, neuronal …

Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation

W Luo, H Xu, L Xu, W Jiang, C Chen, Y Chang, C Liu… - Glia, 2023 - Wiley Online Library
Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune
disease of the central nervous system that is manifested as secondary myelin loss …

An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models

A Dixit, HS Savage, JM Greer - Expert Opinion on Therapeutic …, 2023 - Taylor & Francis
Introduction Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and
neurodegenerative condition affecting the central nervous system (CNS). Although …

The Antioxidant Drug Edaravone Binds to the Aryl Hydrocarbon Receptor (AHR) and Promotes the Downstream Signaling Pathway Activation

C Veroni, S Olla, MS Brignone, C Siguri, A Formato… - Biomolecules, 2024 - mdpi.com
A considerable effort has been spent in the past decades to develop targeted therapies for
the treatment of demyelinating diseases, such as multiple sclerosis (MS). Among drugs with …

Edaravone Oral Suspension: A Neuroprotective Agent to Treat Amyotrophic Lateral Sclerosis

P Singh, P Belliveau, J Towle… - American Journal of …, 2024 - journals.lww.com
Background: Amyotrophic lateral sclerosis (ALS) is characterized by loss of motor neurons
due to degeneration of nerve cells within the brain and spinal cord. Early symptoms include …

[PDF][PDF] Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders. Antioxidants 2022, 11, 923

YH Wu, HL Hsieh - 2022 - academia.edu
The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous
system under stress conditions. HO degrades heme to carbon monoxide, iron, and …