The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …

There is an increasing trend of investigating natural bioactive compounds targeting
pancreatic β‐cells for the prevention/treatment of diabetes mellitus (DM). With the …

Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of
innate immunity and cancer. Recent work has also implicated these kinases in distinctively …

Glucose metabolism is the initiator of a large number of molecular secretory processes in β
cells. Cyclic nucleotides as a second messenger are the main physiological regulators of …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) is a crucial
innate defence mechanism against viral infection in the innate immune system, as it …

Idiopathic pulmonary fibrosis (IPF) results in scarring of the lungs by excessive extracellular
matrix (ECM) production. Resident fibroblasts are the major cell type involved in ECM …

Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and
progression of many diseases, such as inflammation, autoimmune diseases, metabolic …

Amlexanox (AMX) is an azoxanthone drug used for decades for the treatment of mouth
aphthous ulcers and now considered for the treatment of diabetes and obesity. The drug is …

Diabetes, and several diseases related to diabetes, including cancer, cardiovascular
diseases and neurological disorders, represent one of the major ongoing threats to human …

Background Diabetes mellitus (DM) is a chronic metabolic disorder, increasing in the
number of patients and poses a severe threat to human health. Significant advances have …