Ocular drug delivery to the retina: current innovations and future perspectives

HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …

Gold nanoparticles as a potent radiosensitizer: A transdisciplinary approach from physics to patient

S Penninckx, AC Heuskin, C Michiels, S Lucas - Cancers, 2020 - mdpi.com
Over the last decade, a growing interest in the improvement of radiation therapies has led to
the development of gold-based nanomaterials as radiosensitizer. Although the …

A green chemistry approach for synthesizing biocompatible gold nanoparticles

S Gurunathan, JW Han, JH Park, JH Kim - Nanoscale research letters, 2014 - Springer
Gold nanoparticles (AuNPs) are a fascinating class of nanomaterial that can be used for a
wide range of biomedical applications, including bio-imaging, lateral flow assays …

Toxicity of Transition Metal Oxide Nanoparticles: Recent Insights from in vitro Studies

YW Huang, C Wu, RS Aronstam - Materials, 2010 - mdpi.com
Nanotechnology has evolved to play a prominent role in our economy. Increased use of
nanomaterials poses potential human health risk. It is therefore critical to understand the …

Gold nanoparticles downregulate interleukin‐1β‐induced pro‐inflammatory responses

VV Sumbayev, IM Yasinska, CP Garcia, D Gilliland… - Small, 2013 - Wiley Online Library
Abstract Interleukin 1 beta (IL‐1β)‐dependent inflammatory disorders, such as rheumatoid
arthritis and psoriasis, pose a serious medical burden worldwide, where patients face a …

Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution

PS Apaolaza, M Busch, E Asin-Prieto… - Experimental eye …, 2020 - Elsevier
Due to the unique anatomical structure of the eye, ocular drug delivery is a promising
delivery route for the treatment of several ocular diseases, such as the ocular …

Gold nanoparticle-induced cell death and potential applications in nanomedicine

H Sun, J Jia, C Jiang, S Zhai - International journal of molecular sciences, 2018 - mdpi.com
Cell death is crucial to human health and is related to various serious diseases. Therefore,
generation of new cell death regulators is urgently needed for disease treatment …

[HTML][HTML] Nanoparticles in the ocular drug delivery

HY Zhou, JL Hao, S Wang, Y Zheng… - International journal of …, 2013 - ncbi.nlm.nih.gov
Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular
surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina …

Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina – Studies on Nanoparticle Internalization, Apoptosis, Oxidative Stress, Glial- and Microglial Activity

E Söderstjerna, P Bauer, T Cedervall, H Abdshill… - PLoS …, 2014 - journals.plos.org
The complex network of neuronal cells in the retina makes it a potential target of neuronal
toxicity–a risk factor for visual loss. With growing use of nanoparticles (NPs) in commercial …

Maternal exposure to polystyrene nanoplastics causes defective retinal development and function in progeny mice by disturbing metabolic profiles

S Xiong, J He, H Qiu, CAM van Gestel, EK He, Z Qiao… - Chemosphere, 2024 - Elsevier
Abstract Microplastics (MPs) and nanoplastics (NPs) are widely spreading in our living
environment, accumulating in the human body and potentially threating human health. The …