Heat-shock proteins as powerful weapons in vaccine development

A Bolhassani, S Rafati - Expert review of vaccines, 2008 - Taylor & Francis
Heat-shock proteins (HSPs) have been known as multifunctional proteins. They facilitate the
folding and unfolding of proteins, participate in vesicular transport processes, prevent …

Leishmaniasis: vaccine candidates and perspectives

B Singh, S Sundar - Vaccine, 2012 - Elsevier
Leishmania is a protozoan parasite and a causative agent of the various clinical forms of
leishmaniasis. High cost, resistance and toxic side effects of traditional drugs entail …

Exosome secretion by the parasitic protozoan Leishmania within the sand fly midgut

VD Atayde, H Aslan, S Townsend, K Hassani… - Cell reports, 2015 - cell.com
Despite several studies describing the secretion of exosomes by Leishmania in vitro,
observation of their formation and release in vivo has remained a major challenge. Herein …

An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani …

MAA Khan, JQ Ami, K Faisal, R Chowdhury, P Ghosh… - Parasites & vectors, 2020 - Springer
Background Visceral leishmaniasis (VL) caused by dimorphic Leishmania species is a
parasitic disease with high socioeconomic burden in endemic areas worldwide. Sustaining …

Utilizing quantitative proteomics to identify species-specific protein therapeutic targets for the treatment of Leishmaniasis

S Krobthong, Y Yingchutrakul, P Samutrtai… - ACS …, 2022 - ACS Publications
Leishmaniasis is a tropical disease caused by Leishmania parasites, which are transmitted
through the bites of infected sandflies. We focused on the emergence of leishmaniasis in …

Immunoinformatics approach to design a multi-epitope vaccine against cutaneous leishmaniasis

S Naz, A Aroosh, A Caner, EA Şahar, S Toz, Y Ozbel… - Vaccines, 2023 - mdpi.com
Cutaneous Leishmaniasis (CL), a neglected vector-borne disease caused by protozoan
parasite Leishmania major (L. major), is a major public health concern, and the development …

Cocktail of gp63 and Hsp70 induces protection against Leishmania donovani in BALB/c mice

T Kaur, RC Sobti, S Kaur - Parasite immunology, 2011 - Wiley Online Library
The 63‐kDa antigen of Leishmania donovani is a membrane‐anchored matrix
metalloprotease that has been shown to be involved in the infection process. We have …

The genetics of Leishmania virulence

E Bifeld, J Clos - Medical microbiology and immunology, 2015 - Springer
The ability of Leishmania parasites to infect and persist in the antigen-presenting cell
population of their mammalian hosts is dependent on their ability to gain entry to their host …

KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. major

S Bhaumik, R Basu, S Sen, K Naskar, S Roy - Vaccine, 2009 - Elsevier
As vaccine potential of cross-species protection by a candidate antigen is less explored, in
this study we compared cross-specific protective efficacy of Kinetoplastid Membrane Protein …

Identification of Novel Leishmania donovani Antigens that Help Define Correlates of Vaccine-Mediated Protection in Visceral Leishmaniasis

S Bhowmick, N Ali - PloS one, 2009 - journals.plos.org
Visceral leishmaniasis (VL), caused by the intracellular parasite Leishmania donovani is a
major public health problem in the developing world. But there is no effective and safe …