Bartter and Gitelman syndromes are rare inherited tubulopathies characterized by
hypokalaemic, hypochloraemic metabolic alkalosis. They are caused by mutations in at least …

The concentration of intracellular and extracellular potassium is tightly regulated due to the
action of various ion transporters, channels, and pumps, which reside primarily in the kidney …

Most cationic vectors are difficult to avoid the fate of small interfering RNA (siRNA)
degradation following the endosome-lysosome pathway during siRNA transfection. In this …

Mammalian kidneys play an essential role in balancing internal water and salt
concentrations. When water needs to be conserved, the renal medulla produces …

In the kidney, the thick ascending limb (TAL) of the loop of Henle plays a vital role in NaCl
homeostasis and blood pressure regulation. In human and animal models of salt-sensitive …

Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and
electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin …

Abstract Background Mast cells utilize SNAREs (soluble-N-ethyl-maleimide sensitive factor
attachment protein receptors) and SM (Sec1/Munc18) proteins to secrete/exocytose a variety …

Abstract Na+–K+–Cl− cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein
that comes as three splice variants and mediates the cotranslocation of Na+, K+, and Cl …

Molecular regulation of NKCC2 in blood pressure control and... : Current Opinion in Nephrology
and Hypertension Molecular regulation of NKCC2 in blood pressure control and hypertension …

Purpose of review The thick ascending limb (TAL) of loop of Henle is essential for NaCl,
calcium and magnesium homeostasis, pH balance and for urine concentration. NKCC2 is …