This review on the interplay between malaria, antimalarial drugs, and hemozoin crystals is
directed, on one hand, to biologists and pharmaceutical chemists who wish to have a …

Artemisinins have become essential antimalarial drugs for increasingly widespread drug-
resistant malaria strains. Although tremendous efforts have been devoted to decipher how …

Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …

The discovery of artemisinin more than 30 years ago provided a completely new antimalarial
structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1 …

Abstract The Mycobacterium tuberculosis (Mtb) DosRST two-component regulatory system
promotes the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help …

The most widely used antimalarial drugs belong to the quinoline family. Their mode of action
has not been characterized at the molecular level in vivo. We report the in vivo mode of …

Malaria is an increasing worldwide threat, with more than three hundred million infections
and one million deaths every year. The worlds poorest are the worst affected, and many treat …

Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials
based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance …

The antimalarial trioxanes, exemplified by the naturally occurring sesquiterpene lactone
artemisinin and its semi-synthetic derivatives, contain an endoperoxide pharmacophore that …

An Over Four Millennium Story Behind Qinghaosu (Artemisinin)-A Fantastic Antimalarial Drug
from a Traditional Chinese Herb Page 1 Current Medicinal Chemistry, 2003, 10, 2197-2230 2197 …