The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

The actin cytoskeleton plays a crucial role in many cellular processes while its
reorganization is important in maintaining cell homeostasis. However, in the case of cancer …

Besides its essential and well established role as a component of the cytoskeleton, actin is
also present in the cell nucleus, where it has been linked to many processes that control …

Metastasis causes death of 90% of cancer patients, so it is the most significant issue
associated with cancer disease. Thus, it is no surprise that many researchers are trying to …

The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …

β-Actin, once thought to be an exclusively cytoplasmic protein, is now known to have
important functions within the nucleus. Nuclear β-actin associates with and functions in …

While actin was discovered in the nucleus over 50 years ago, research lagged for decades
due to strong skepticism. The revitalization of research into nuclear actin occurred after it …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Amphibian oocytes can rapidly and efficiently reprogram the transcription of transplanted
somatic nuclei. To explore the factors and mechanisms involved, we focused on nuclear …

Actin participates in several essential processes in the cell nucleus. Even though the
presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes …