Protein is the basis of life substance and the main undertaker of life activities. The study of
protein structure and the interaction between protein and other molecules is the basis of …

Protein folding is a fascinating, not fully understood phenomenon in biology. Molecular
dynamics (MD) simulations are an invaluable tool to study conformational changes in …

The genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes 16
non-structural (Nsp) and 4 structural proteins. Among the Nsps, Nsp1 inhibits host gene …

Insertion of an immunogenic epitope at the C-terminus of ferritin has shown the potential to
produce a stable and efficacious vaccine. There is however limited understanding of how C …

Pesticides can affect the health of individual organisms and the function of the entire
ecosystem. Therefore, thorough assessment of the risks associated with the use of …

Many proteins form amyloid fibrils only under conditions when the probability of transition
from a native (structured, densely packed) to an intermediate (labile, destabilized) state is …

The properties of biological materials like proteins and nucleic acids are largely determined
by their primary sequence. While certain segments in the sequence strongly influence …

Glycolysis is a highly conserved biochemical process that involves the sequential
conversion of glucose to pyruvate and the generation of adenosine triphosphate (ATP) …

Point mutations in gene sequence often lead to protein misfolding or destabilization which is
a well-known cause of a number of loss-of-function diseases. The carriers of point mutations …

Detecting the folding/unfolding pathways of biological macromolecules is one of the urgent
problems of molecular biophysics. The unfolding of bacterial luciferase from Vibrio harveyi is …