Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery

E Marsault, ML Peterson - Journal of medicinal chemistry, 2011 - ACS Publications
Macrocycles occupy a unique segment of chemical space. In the past decade, their chemical
diversity expanded significantly, supported by advances in bioinformatics and synthetic …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Peptidomimetics via modifications of amino acids and peptide bonds

I Avan, CD Hall, AR Katritzky - Chemical Society Reviews, 2014 - pubs.rsc.org
Peptidomimetics represent an important field in chemistry, pharmacology and material
science as they circumvent the limitations of traditional peptides used in therapy. Self …

Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Peptoid origins

RN Zuckermann - Peptide Science, 2011 - Wiley Online Library
Peptoid oligomers were initially developed as part of a larger basic research effort to
accelerate the drug‐discovery process in the biotech/biopharma industry. Their ease of …

[HTML][HTML] Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics

G Koopmanschap, E Ruijter… - Beilstein Journal of …, 2014 - beilstein-journals.org
In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

Design, synthesis, assembly, and engineering of peptoid nanosheets

EJ Robertson, A Battigelli, C Proulx… - Accounts of Chemical …, 2016 - ACS Publications
Conspectus Two-dimensional (2D) atomically defined organic nanomaterials are an
important material class with broad applications. However, few general synthetic methods …

Sequence-defined bioactive macrocycles via an acid-catalysed cascade reaction

M Porel, DN Thornlow, NN Phan, CA Alabi - Nature chemistry, 2016 - nature.com
Synthetic macrocycles derived from sequence-defined oligomers are a unique structural
class whose ring size, sequence and structure can be tuned via precise organization of the …

Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics

RMJ Liskamp, DTS Rijkers, JAW Kruijtzer… - …, 2011 - Wiley Online Library
Despite their enormous diversity in biological function and structure, peptides and proteins
are endowed with properties that have induced and stimulated the development of …