Pluronic® block copolymers have been used extensively in a variety of pharmaceutical
formulations including delivery of low molecular mass drugs and polypeptides. This review …

Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the
body signal transduction mechanisms involved in inflammation, differentiation, proliferation …

Quantifying the content of metal‐based anticancer drugs within single cancer cells remains
a challenge. Here, we used single‐cell inductively coupled plasma mass spectrometry to …

The destruction of cells capable of initiating and maintaining leukemia challenges the
treatment of human acute myeloid leukemia. Recently, CD34+/CD38− leukemia progenitors …

Purpose. Previous studies have demonstrated that Pluronic block copolymers
hypersensitize multiple drug resistant (MDR) cancer cells, drastically increasing the cytotoxic …

Abstract Cisplatin [cis-diaminodichloroplatinum (II)(CDDP)] is one of the most widely used
and effective therapeutic agents for many kinds of cancers. However, its efficiency is limited …

Some cancers like melanoma and pancreatic and ovarian cancers, for example, commonly
display resistance to chemotherapy, and this is the major obstacle to a better prognosis of …

Purpose. Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic
P85 (P85) block copolymer increases apical (AP) to basolateral (BL) transport of rhodamine …

Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …

Pluronic® block copolymers are known to sensitize multidrug resistant (MDR) tumors with
respect to various anticancer agents, particularly, anthracycline antibiotics. After completion …