In multicellular organisms, homeostasis is maintained through a balance between cell
proliferation and cell death. Although much is known about the control of cell proliferation …

Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the
random coil. The five following examples suggest that native protein structure can …

Purpose Resistance to chemotherapy-induced apoptosis represents a major obstacle to
cancer control. Overexpression of Bcl-2 is seen in multiple tumor types and targeting Bcl-2 …

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that
restore the normal apoptotic pathways have the potential for effectively treating cancers that …

ABT-737 is a novel and potent Bcl-2 antagonist with single-agent activity against small-cell
lung cancer (SCLC) cell lines. Here, we evaluated the contribution of Bcl-2 family members …

We review the molecular pathogenesis of lung cancer including alterations in dominant
oncogenes, recessive oncogenes/tumor suppressor genes, alterations in growth regulatory …

BACKGROUND: Bioactive marine molecules have recently received considerable attention
for their nutraceutical characteristics. Considering the ever-increasing demand of …

Introduction Altered epigenetic map is frequently observed in cancer and recent
investigations have demonstrated a pertinent role of epigenetic modifications in the …

The ability of a cancer cell to avoid apoptosis is crucial to tumorigenesis and can also
contribute to chemoresistance. The Bcl-2 family of prosurvival proteins (Bcl-2, Bcl-XL, Bcl-w …

We have investigated the expression of bcl-2 protein in a panel of small cell lung carcinoma
(SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 …