The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus that spread
worldwide from 2019 causing the Coronavirus disease 19 (COVID-19) pandemic. SARS …

Importance The benefit of high-dose dexamethasone and oxygenation strategies vs
standard of care for patients with severe acute hypoxemic respiratory failure (AHRF) caused …

Purpose We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients
with coronavirus disease 2019 (COVID-19) and severe hypoxaemia in the international …

Dexamethasone (DEX) has been widely used to treat a variety of diseases, including
autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19 …

Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …

The precocity and efficacy of the vaccines developed so far against COVID-19 has been the
most significant and saving advance against the pandemic. The development of vaccines …

Background Low-dose corticosteroids have been shown to reduce mortality for patients with
COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation …

Coronavirus disease 2019 (COVID-19) is a predominantly respiratory infectious disease
caused by novel coronavirus infection (SARS-CoV-2), respiratory failure is the main clinical …

Three and a half years after the pandemic outbreak, now that WHO has formally declared
that the emergency is over, COVID-19 is still a significant global issue. Here, we focus on …