Progesterone-related immune modulation of pregnancy and labor

NM Shah, PF Lai, N Imami, MR Johnson - Frontiers in endocrinology, 2019 - frontiersin.org
Pregnancy involves a complex interplay between maternal neuroendocrine and
immunological systems in order to establish and sustain a growing fetus. It is thought that the …

Diabetic gastroparesis: principles and current trends in management

S Krishnasamy, TL Abell - Diabetes Therapy, 2018 - Springer
This article is a comprehensive review of diabetic gastroparesis, defined as delayed or
disordered gastric emptying, including basic principles and current trends in management …

Progesterone receptor signaling in the uterus is essential for pregnancy success

DI Cope, D Monsivais - Cells, 2022 - mdpi.com
The uterus plays an essential role in the reproductive health of women and controls critical
processes such as embryo implantation, placental development, parturition, and …

Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas

J Goad, J Rudolph, M Zandigohar, M Tae… - Human …, 2022 - academic.oup.com
STUDY QUESTION What are the cellular composition and single-cell transcriptomic
differences between myometrium and leiomyomas as defined by single-cell RNA …

Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth

JA Keelan - Journal of Reproductive Immunology, 2018 - Elsevier
The central role of inflammatory processes in labour and delivery is now well-recognised.
However, the biomolecular, immunological and endocrine mechanisms involved in the …

Progesterone receptor regulation of uterine adaptation for pregnancy

SP Wu, R Li, FJ DeMayo - Trends in Endocrinology & Metabolism, 2018 - cell.com
Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

BM Arman, NK Binder, N de Alwis… - …, 2023 - rep.bioscientifica.com
In brief Preterm birth is the leading cause of perinatal morbidity and mortality; however,
current therapies offer limited efficacy to delay birth and improve neonatal outcomes. This …

Oral progesterone for the prevention of recurrent preterm birth: systematic review and metaanalysis

RC Boelig, L Della Corte, S Ashoush… - American journal of …, 2019 - Elsevier
Objective Data The purpose of this study was to perform a systematic review and
metaanalysis of randomized controlled trials on oral progesterone compared with placebo or …

Estrogen Receptor (ER) and Progesterone Receptor (PgR) Expression in Endometrial Cancer—An Immunohistochemical Assessment

S Przewoźny, J Rogaliński, M de Mezer, A Markowska… - Diagnostics, 2024 - mdpi.com
Endometrial cancer (EC) is one of the most common types of cancer in Poland and
worldwide. Many risk factors lead to the pathogenesis of this disease, such as lifestyle …

Myometrial progesterone receptor determines a transcription program for uterine remodeling and contractions during pregnancy

SP Wu, T Wang, ZC Yao, MC Peavey, X Li, L Zhou… - PNAS …, 2022 - academic.oup.com
The uterine myometrium expands and maintains contractile quiescence before parturition.
While the steroid hormone progesterone blocks labor, the role of progesterone signaling in …