Efficient and reproducible transgenesis facilitates and accelerates research using genetic
model organisms. Here, we describe a mo dular s afe-harbor t ransgene i nsertion (MosTI) …

Auxin-inducible degradation is a powerful tool for the targeted degradation of proteins with
spatiotemporal control. One limitation of the auxin-inducible degradation system is that not …

Figure 1. The histamine-gated chloride channel HisCl1 effectively paralyzes transgenic
array animals: AD. Doseresponse relationship and time-course for the paralysis of …

Spermatogenesis is the process through which mature male gametes are formed and is
necessary for the transmission of genetic information. While much work has established how …

A core tenet of synthetic biology is that well-characterized regulatory elements are essential
for engineering biological systems. Here, we characterize the specificity and expression …

Synthetic biology relies on standardized biological parts (BioParts), and we aim to identify
cell-specific promoters for every class of neuron in C. elegans. Here, we characterize a short …

Apical extracellular matrices (aECMs) are associated with all epithelia and form a protective
layer against biotic and abiotic threats in the environment. Despite their importance, we lack …

The apical extracellular matrix acts as crucial barrier, and communicates with the epidermis
to trigger protective responses following injury or infection. In C. elegans, we previously …

Biological parts (BioParts) are modular and standardized DNA sequences that encode
biological functions and contribute to the efficient biological engineering of complex …

Apical extracellular matrices (aECMs) are associated with all epithelia and form a protective
layer against biotic and abiotic threats in the environment. C. elegans molting offers a …