Full circle: a brief history of cohesin and the regulation of gene expression
JA Horsfield - The FEBS journal, 2023 - Wiley Online Library
The cohesin complex has a range of crucial functions in the cell. Cohesin is essential for
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …
Cohesin mutations in acute myeloid leukemia
A Boucher, J Murray, S Rao - Leukemia, 2024 - nature.com
The cohesin complex, encoded by SMC3, SMC1A, RAD21, and STAG2, is a critical
regulator of DNA-looping and gene expression. Over a decade has passed since recurrent …
regulator of DNA-looping and gene expression. Over a decade has passed since recurrent …
[HTML][HTML] How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization
TM Gemeinhardt, RM Regy, AJ Mendiola… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The Polycomb Group (PcG) complex PRC1 represses transcription, forms condensates in
cells, and modifies chromatin architecture. These processes are connected through the …
cells, and modifies chromatin architecture. These processes are connected through the …
De Novo Polycomb Recruitment and Repressive Domain Formation
IA Hernández-Romero, VJ Valdes - Epigenomes, 2022 - mdpi.com
Every cell of an organism shares the same genome; even so, each cellular lineage owns a
different transcriptome and proteome. The Polycomb group proteins (PcG) are essential …
different transcriptome and proteome. The Polycomb group proteins (PcG) are essential …
High-throughput Oligopaint screen identifies druggable regulators of genome folding
Although the molecular rules governing genome organization are being quickly elucidated,
relatively few proteins regulating this process have been identified. To address this gap, we …
relatively few proteins regulating this process have been identified. To address this gap, we …