The global diabetes epidemic and its complications are increasing, thereby posing a major
threat to public health. A comprehensive understanding of diabetes mellitus (DM) and its …

Pancreatic beta-cell death has been established as a critical mediator in the progression of
type 1 and type 2 diabetes mellitus. Beta-cell death is associated with exacerbating …

Ferroptosis, an emerging form of regulated programmed cell death, has garnered significant
attention in the past decade. It is characterized by the accumulation of lipid peroxides and …

Simple Summary In the realm of colorectal cancer treatment, drug resistance is a formidable
obstacle. However, a ray of hope emerges in the form of ferroptosis, a unique iron-driven cell …

Background Recent studies have shown that the accumulation of free iron and lipid
peroxides will trigger a new form of cell death—ferroptosis. This form of cell death is …

Alzheimer's disease (AD) as a common neurodegenerative disease showed progressive
cognitive dysfunction and behavioral impairment. Currently, the deposition of amyloid β …

Introduction Recently, the involvement of ferroptotic cell death in the reduction of β-cell mass
in diabetes has been demonstrated. To elucidate the mechanisms of β-cell ferroptosis and …

Ferroptosis, as a way of cell death, participates in the body's normal physiological and
pathological regulation. Recent studies have shown that ferroptosis may damage glucose …

Mounting evidence points to a link between growth differentiation factor-15 (GDF15)
expression and the onset and progression of diabetes mellitus. However, the exact role of …

Aims In this study, we investigated the role of the FTO gene in pancreatic β-cell biology and
its association with type 2 diabetes (T2D). To address this issue, human pancreatic islets …