Microtubule targeting agents as cancer chemotherapeutics: an overview of molecular hybrids as stabilizing and destabilizing agents

A Devi Tangutur, D Kumar… - Current topics in …, 2017 - ingentaconnect.com
Microtubules form crucial dynamic structural cellular components of the cell and are
composed of the alpha beta tubulin heterodimers. Microtubules are involved in a wide …

A drug repositioning success: The repositioned therapeutic applications and mechanisms of action of thalidomide

GG Amare, BG Meharie… - Journal of Oncology …, 2021 - journals.sagepub.com
Background Thalidomide is the most teratogenic human medicine ever marketed and was
associated with birth defects in approximately 10,000 children in the 1960s. The …

Computer-aided drug discovery approaches against the tropical infectious diseases malaria, tuberculosis, trypanosomiasis, and leishmaniasis

PM Njogu, EM Guantai, E Pavadai… - ACS infectious …, 2016 - ACS Publications
Despite the tremendous improvement in overall global health heralded by the adoption of
the Millennium Declaration in the year 2000, tropical infections remain a major health …

Designed hybrid compounds for tropical parasitic diseases

PM Njogu, J Okombo, K Chibale - Design of Hybrid Molecules for Drug …, 2017 - Elsevier
Over the last century, the world has experienced a gradual but steady epidemiological
transition in the pattern of diseases hallmarked by a shift in the causes of mortality and …

[PDF][PDF] Biotechnological Aspects and Pharmaceutical Applications of Bacterial Proteases

A Aladdin, RA Alsaheb, A Pareek, NZ Othman… - Der Pharmacia …, 2017 - academia.edu
Proteases enzymes are capable of hydrolyzing peptide bonds in proteins. They can be
found in all living organisms. Bacterial proteases enzymes have great pharmaceutical …