AlphaFold2 and its applications in the fields of biology and medicine
Z Yang, X Zeng, Y Zhao, R Chen - Signal Transduction and Targeted …, 2023 - nature.com
Abstract AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
Amyloid polymorphism in the protein folding and aggregation energy landscape
J Adamcik, R Mezzenga - Angewandte Chemie International …, 2018 - Wiley Online Library
Protein folding involves a large number of steps and conformations in which the folding
protein samples different thermodynamic states characterized by local minima. Kinetically …
protein samples different thermodynamic states characterized by local minima. Kinetically …
Fuzziness and frustration in the energy landscape of protein folding, function, and assembly
S Gianni, MI Freiberger, P Jemth… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Are all protein interactions fully optimized? Do suboptimal interactions
compromise specificity? What is the functional impact of frustration? Why does evolution not …
compromise specificity? What is the functional impact of frustration? Why does evolution not …
[HTML][HTML] Assessing the accuracy of physical models used in protein-folding simulations: quantitative evidence from long molecular dynamics simulations
Highlights•The accuracy of physical models used in protein-folding simulations is
assessed.•This assessment is based on data from very long molecular dynamics …
assessed.•This assessment is based on data from very long molecular dynamics …
Chiral self-assembly of peptides: Toward the design of supramolecular polymers with enhanced chemical and biological functions
Chirality is one of the most important structural features in biological systems. Peptides, as a
class of small biomolecules, can self-assemble into various chiral supramolecular polymers …
class of small biomolecules, can self-assemble into various chiral supramolecular polymers …
Protein dynamism and evolvability
N Tokuriki, DS Tawfik - Science, 2009 - science.org
The traditional view that proteins possess absolute functional specificity and a single, fixed
structure conflicts with their marked ability to adapt and evolve new functions and structures …
structure conflicts with their marked ability to adapt and evolve new functions and structures …
The protein folding 'speed limit'
How fast can a protein possibly fold? This question has stimulated experimentalists to seek
fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the …
fast folding proteins and to engineer them to fold even faster. Proteins folding at or near the …
Atomic-level description of ubiquitin folding
S Piana, K Lindorff-Larsen… - Proceedings of the …, 2013 - National Acad Sciences
Equilibrium molecular dynamics simulations, in which proteins spontaneously and
repeatedly fold and unfold, have recently been used to help elucidate the mechanistic …
repeatedly fold and unfold, have recently been used to help elucidate the mechanistic …
Preformed structural elements feature in partner recognition by intrinsically unstructured proteins
M Fuxreiter, I Simon, P Friedrich, P Tompa - Journal of molecular biology, 2004 - Elsevier
Intrinsically unstructured proteins (IUPs) are devoid of extensive structural order but often
display signs of local and limited residual structure. To explain their effective functioning, we …
display signs of local and limited residual structure. To explain their effective functioning, we …